Is the KPV half-life figure everyone quotes actually sourced?

Started by peptide_dev · · 19 replies · 2,869 views

Someone talk me out of this.

Every vendor page for KPV says basically the same thing in the same order, which makes me think none of them wrote it.

What bugs me about KPV is how confident everyone is. Nobody hedges. Everyone has a protocol.

Genuinely open to being corrected on this.

19 comments 2,869 views Jump to comments

19 comments showing 4

80

I would want to see this replicated by a group that is not the one who published the original before I changed anything.

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80

Testing desk here. Every specimen page links the full laboratory report, including the method and the lot. If something in one of them is unclear, say which and we will explain it.

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0

Reversed-phase HPLC with UV detection at 214nm is the standard here because the peptide bond absorbs there. If a vendor reports purity without stating the method or wavelength, the number is not comparable to anything.

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57

The figure everyone quotes traces back to a single 2019 paper with n=8. It gets cited as though it were established and it is really not.

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