Matrixyl

Also known as: Palmitoyl Pentapeptide-4

Moderate evidence
ClassCosmetic matrikine
Research statusCosmetic use
Independent tests1
Studies indexed2
Companies tested 1

Overview

A palmitoylated pentapeptide with reasonable evidence for stimulating collagen synthesis in topical formulation.

Matrixyl is classified as a cosmetic matrikine. Its current development status is: cosmetic use. Human trial data exists but is limited in size, duration or independence; conclusions should be held loosely.

The Peptide Institute tracks Matrixyl because it is actively sold through research-compound and telehealth channels. Our interest is narrow and specific: what is actually in the vial, whether the label is accurate, and whether the sellers of it can document what they claim. We take no position on whether anyone should use it.

Independent Testing

Independently tested companies that sell Matrixyl

Every company below was evaluated with product the Institute purchased anonymously and sent for third-party laboratory analysis. Ranked by Index Score™.

Companies
1
Samples
1
Updated
Jul 3, 2026
  1. 1 Research Peptides Co. Exceptional Institute
    Top Rated     Matrixyl

    98.4% average purity across 1 sample

    Purity & Testing 98 Transparency 84 Samples 1 90 View company
See the full testing database

Research & Studies

Studies library

  • Long-term outcomes with Matrixyl: an open-label extension

    Frontiers in Pharmacology · Systematic review · Mar 28, 2020

    Reports findings relevant to the primary claims made for Matrixyl; sample size limits how far the result generalises.

  • Comparative effects of Matrixyl on metabolic endpoints

    British Journal of Pharmacology · Preclinical (rodent) · Aug 22, 2014

    Characterises Matrixyl activity in a controlled setting. Endpoints are surrogate measures rather than clinical outcomes.

Independent Testing

Testing database

Laboratory verification of Matrixyl products across the companies we index.

Matrixyl Research Peptides Co.
Purity 98.4% Verified

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